Mycobacterium tuberculosis infection associated immune perturbations correlate with antiretroviral immunity.
Burcu TepekuleLisa JörimannCorinne D SchenkelLennart OpitzJasmin TschumiRebekka WolfensbergerKathrin NeumannKatharina KusejkoMarius ZeebLucas BoeckMarisa KälinJulia NotterHansjakob FurrerMatthias HoffmannHans H HirschAlexandra CalmyMatthias CavassiniNiklaus D LabhardtEnos BernasconiKarin J MetznerDominique L BraunHuldrych F GünthardRoger D KouyosFergal DuffyJohannes Nemethnull nullPublished in: bioRxiv : the preprint server for biology (2023)
In people with HIV-1 (PWH), MTB infection is associated with a perturbation of the PBMC transcriptome independently of re-exposure to MTB specific antigen.MTB infection is associated with a shift away from Type 1 Interferon towards a trained immunity type phenotype.The perturbations associated with MTB infection correlate with improved retroviral control and are lost during progression to active tuberculosis.