Molecular characteristics and clinical outcomes of complex ALK rearrangements identified by next-generation sequencing in non-small cell lung cancers.
Peiyi XiaLan ZhangPan LiEnjie LiuWencai LiJianying ZhangHui LiXiaoxing SuGuozhong JiangPublished in: Journal of translational medicine (2021)
This study firstly reveals the molecular characteristics and clinical outcomes of complex ALK rearrangements in NSCLC, sensitive to ALK inhibitors treatment, and highlights the importance of utilizing probes tilling the selected intronic regions of fusion partner genes in DNA-based NGS for accurate fusion detection. RNA and protein level assay may be critical in validating the function of complex ALK rearrangements in clinical practice for optimal treatment decision.
Keyphrases
- advanced non small cell lung cancer
- clinical practice
- small cell lung cancer
- circulating tumor
- small molecule
- gene expression
- high throughput
- genome wide
- high resolution
- stem cells
- combination therapy
- decision making
- bone marrow
- photodynamic therapy
- living cells
- hiv infected
- fluorescence imaging
- hiv testing
- sensitive detection