Is polypharmacy associated with difficulty taking medicines in people aged ≥85 living at home? Findings from the Newcastle 85+ Study.

It is unclear whether polypharmacy is associated with difficulty taking medications amongst people aged≥85 living at home. This is despite the projected decline in availability of family carers, who may support independent living. Using Newcastle 85+ Study data and mixed-effects modelling, we investigated the association between polypharmacy and difficulty taking medications amongst 85-year-olds living at home, over a 10-year time-period. Polypharmacy was not associated with difficulty taking medications as either a continuous (OR=0.99 [0.91-1.08]) or categorical variable (5-9 medications, OR=0.69 [0.34-1.41]; ≥10 medications, OR=0.85 [0.34-2.07]). The significant predictors included disability, visual and cognitive impairment. Our results suggest that people aged≥85 living at home with disability, visual and/or cognitive impairment will have difficulty taking their medications, regardless of how many they are prescribed. Therefore, healthcare professionals should routinely ask about, assess and address problems that these patient groups may have with taking their medicines, independent of the number of drugs taken.