Investigation of the Influence of Functionalization Strategy on Urea 2D MOF Catalytic Performance.

Urea-functionalized MOFs with unique properties have recently been used as efficient platforms to conduct organocatalytic reactions. To gain more insight into the key factors which govern an efficient organocatalytic reaction in urea-MOFs, two different urea-containing 2D MOFs TMU-58 ([Zn(L1)(oba)].CH 3 CN) and TMU-83 ([Zn(L2)(oba)].DMF), where L1 = (1 E ,5 E )-1,5-bis(1-(pyridine-4-ylethylidene)carbonohydrazide, L2 = (1 E ,5 E )-1,5-bis(1-(pyridine-4-ylmethylene)carbonohydrazide, and oba = 4,4'-oxybisbenzoic acid, with abundant accessible active sites, were selected and examined in the methanolysis of styrene oxide. TMU-58 with the ability to form a two-point H-bond with different substrates revealed a high organocatalytic efficiency in the regioselective ring opening of styrene oxide. The catalytic activation of epoxide oxygen by the urea N-H functional sites, followed by the nucleophilic attack of methanol at the benzylic carbon led to the formation of 2-methoxy-2-phenylethanol as the major product. DFT calculations were also performed to investigate the acidic strength of the urea hydrogens in both TMU-58 and TMU-83 structures as a major factor to conduct an efficient catalytic reaction. The results indicated the more acidic nature of the urea hydrogens in TMU-83; however, its catalytic efficiency was remarkably reduced due to the inappropriate orientation of the active interaction sites within the framework revealing the importance of proper orientation of the urea hydrogens in conducting an efficient organocatalytic reaction. The current study provides a comparative study on the function-property relationship in 2D MOF assemblies which has not been explored so far.