Increasing Drug Resistance Among Persons With Tuberculosis in Massachusetts, 2009-2018.

Jared J EddyKavita M GadaniAndrew TibbsJohn BernardoJennifer CochranLaura F White Charles R Horsburgh Karen R Jacobson

Published in: Open forum infectious diseases (2020)

We examined Massachusetts tuberculosis surveillance data from to 2009 to 2018. Of 1533 culture-confirmed cases, 190 (12.4%) demonstrated resistance to isoniazid including 32 (2.1%) with rifampin resistance. In multivariable analysis, isoniazid resistance increased significantly over time (per-year odds ratio = 1.07, 95% confidence interval = 1.01-1.13, P = .018) and was associated with younger age, foreign birth, and prior tuberculosis treatment.

Keyphrases

mycobacterium tuberculosis
pulmonary tuberculosis
hiv aids
public health
emergency department
adverse drug
pregnant women
big data
machine learning
hiv infected