ROC study and SUV threshold using quantitative multi-modal SPECT for bone imaging.
Alexander Hans VijaP A BartensteinJ W FroelichT KuwertH MacapinlacC P DaignaultN GowdaO HadjievJ HephzibahP HuangH IlhanA JessopM CachovanJ MaX DingD SpenceG PlatschZ SzaboPublished in: European journal of hybrid imaging (2019)
The incorporation of high-resolution CT-based tissue delineation in SPECT reconstruction (xSPECT Bone) provides better resolution and detects smaller lesions (6 ml), and the CT component facilitates lesion characterization. Our approach increases confidence, concordance, and accuracy for readers with a wide range of experience. The xB method retained high reading accuracy, despite the unfamiliar image presentation, having greatest impact for smaller lesions, and better localization of foci relative to bone anatomy. The quantitative assessment yielded an SUV-threshold for sensitively distinguishing benign and malignant lesions. Ongoing efforts shall establish clinically usable protocols and SUV thresholds for decision-making based on quantitative SPECT.
Keyphrases
- high resolution
- bone mineral density
- pet ct
- decision making
- computed tomography
- soft tissue
- image quality
- bone loss
- contrast enhanced
- dual energy
- bone regeneration
- mass spectrometry
- positron emission tomography
- body composition
- magnetic resonance imaging
- postmenopausal women
- high speed
- single molecule
- machine learning
- tandem mass spectrometry