Synthesis of a Novel Gold(I) Complex and Evaluation of Its Anticancer Properties in Breast Cancer Cells.

Haseeb Ahmad KhanAnvarhusein Abdulkadir IsabAbdullah Saleh AlhomidaMansour Khalil GatashehAli Rashid AlhoshaniBashayr Ahmed AldhafeeriN Rajendra Prasad

Published in: Anti-cancer agents in medicinal chemistry (2024)

The lower concentration of PBTDG produced similar cytotoxicity and apoptotic effects that were caused by a comparatively higher concentration of known anticancer drug (sorafenib). The anticancer effects of PBTDG are attributed to its tendency to disrupt mitochondrial membrane potential, induction of apoptosis and generation of ROS. Further studies are warranted to test the anticancer effects of PBTDG in animal models of cancer.

Keyphrases

cell death
oxidative stress
breast cancer cells
papillary thyroid
dna damage
cell cycle arrest
endoplasmic reticulum stress
emergency department
squamous cell
young adults
reactive oxygen species
case control
electronic health record
childhood cancer