Post-transplant primary central nervous system lymphoma after Epstein-Barr virus cerebellitis.
Cristina Valencia SanchezKristen K SteenersonKatalin KelemenRobert OrensteinShimon KusneMarie F GrillPublished in: Journal of neurovirology (2019)
Post-transplantation lymphoproliferative disorder (PTLD) is a complication of solid organ and hematopoietic stem cell transplantation. Cases with isolated central nervous system (CNS) disease are rare. Epstein-Barr virus (EBV) plays a causative role. We present a patient with EBV cerebellitis documented 5 months prior to development of primary CNS PTLD (PCNS-PTLD). This case report demonstrates progression from EBV CNS infection to lymphoproliferative disorder, highlighting the importance of serial clinical and imaging monitoring in transplant patients post-EBV CNS infection. PCNS-PTLD should always be considered in the differential diagnosis for transplant patients presenting with CNS symptoms, even in cases with no evidence of EBV viremia. Earlier diagnosis and appropriate treatment could result in improved outcomes.
Keyphrases
- epstein barr virus
- diffuse large b cell lymphoma
- blood brain barrier
- case report
- end stage renal disease
- chronic kidney disease
- ejection fraction
- high resolution
- newly diagnosed
- stem cells
- type diabetes
- prognostic factors
- acute myeloid leukemia
- peritoneal dialysis
- skeletal muscle
- depressive symptoms
- sleep quality
- mesenchymal stem cells
- insulin resistance