Investigation of the Relationship Between Fok1 and Col1A1 Gene Polymorphisms and Development of Treatment-Related Bone Complications in Children with Acute Lymphoblastic Leukemia

Melek Erdem Özlem Tüfekçi Gürocak Sefa Kızıldağ Şebnem Yılmaz Deniz Kızmazoğlu Berna Eroğlu Filibeli Hale Ören

Published in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2018)

The development of therapy-induced bone mineral loss and osteonecrosis in children with ALL is frequent and the risk is especially higher in children aged ≥10 years and with vitamin D deficiency. The association between Col1A1 Sp1-binding site gene polymorphisms and osteonecrosis has to be assessed in a larger group of ALL survivors.

Keyphrases

young adults
acute lymphoblastic leukemia
bone mineral density
risk factors
stem cells
drug induced
oxidative stress
bone loss
allogeneic hematopoietic stem cell transplantation
acute myeloid leukemia
diabetic rats
bone regeneration
combination therapy