Influence of HLA-A, -B, -DR Polymorphisms on the Severity of COVID-19: A Case-Control Study in the Iranian Population.

Parisa Mashayekhi Mir Davood Omrani Zeynab YassinAli DehghanifardLeila AshouriSara Sadat Aghabozorg AfjehZahra Shabanzadeh

Published in: Archives of Iranian medicine (2023)

Our results confirmed the evidence for the association of HLA alleles with COVID-19 outcomes. We found that HLA-A*11 and HLA-DRB1*14 alleles may be susceptibility factors for severe COVID-19, while HLA-B*52 may be a protective factor. These findings provide new insight into the pathogenesis of COVID-19 and help patient management.

Keyphrases

coronavirus disease
sars cov
respiratory syndrome coronavirus
early onset
skeletal muscle