Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in patients on chronic dialysis: a nationwide registry study.

Solène M LavilleClémence BechadeMarc BauwensHenri Vacher CoponatGabriel ChoukrounSophie Liabeufnull null

Published in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association (2024)

In a large group of dialysis patients initiating an oral anticoagulant, the off-label use of DOACs was associated with a significantly lower risk of thromboembolic events and a non-significantly lower risk of bleeding, relative to VKA use. This provides reassurance regarding the off-label use of DOACs in people on dialysis.

Keyphrases

end stage renal disease
chronic kidney disease
direct oral anticoagulants
peritoneal dialysis
atrial fibrillation
venous thromboembolism
ejection fraction
newly diagnosed
prognostic factors
patient reported outcomes