Circulating amino acid levels and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition and UK Biobank cohorts.
Joseph A RothwellJelena BeševićNiki DimouMarie BreeurNeil MurphyMazda JenabRoland WedekindVivian ViallonPietro FerrariDavid AchaintreAudrey GicquiauSabina RinaldiAugustin ScalbertInge HuybrechtsCornelia PrehnJerzy AdamskiAmanda J CrossHector KeunMarc Chadeau-HyamMarie-Christine Boutron-RuaultKim OvervadChristina C DahmTherese Haugdahl NøstTorkjel M SandangerGuri SkeieRaul Zamora-RosKostas K TsilidisFabian EichelmannMatthias B SchulzeBethany van GuelpenLinda VidmanMaria-José SánchezPilar AmianoEva ArdanazKarl Smith-ByrneRuth TravisVerena KatzkeRudolf KaaksJeroen W G DerksenSandra Colorado-YoharRosario TuminoBas Bueno-de-MesquitaPaolo VineisDomenico PalliFabrizio PasanisiAnne Kirstine EriksenAnne TjønnelandGianluca SeveriMarc J GunterPublished in: BMC medicine (2023)
Higher circulating levels of histidine were associated with a lower risk of colorectal cancer in two large prospective cohorts. Further research to ascertain the role of histidine metabolism and potentially that of glutamine in colorectal cancer development is warranted.