Evaluating the efficacy and mechanism of metformin targets on reducing Alzheimer's disease risk in the general population: a Mendelian randomisation study.
Jie ZhengMin XuVenexia M WalkerJinqiu YuanRoxanna Korologou-LindenJamie RobinsonPeiyuan HuangStephen BurgessShiu Lun Au YeungShan LuoMichael V HolmesGeorge Davey SmithGuang NingWeiqing WangTom R GauntYufang BiPublished in: Diabetologia (2022)
Metformin use may cause reduced Alzheimer's disease risk in the general population. Mitochondrial function and the NDUFA2 gene are plausible mechanisms of action in dementia protection.