Harnessing radiotherapy-induced NK-cell activity by combining DNA damage-response inhibition and immune checkpoint blockade.

Emmanuel C PatinMagnus T DillonPablo NenclaresLorna GroveHeba SolimanIsla LeslieDavina NorthcoteGalabina BozhanovaEva Crespo-RodriguezHolly BaldockHarriet WhittockGabriella BakerJoan KyulaJeane GuevaraAlan A MelcherJames HarperHormas GhadiallySimon SmithMalin Pedersen Martin McLaughlin Kevin J Harrington

Published in: Journal for immunotherapy of cancer (2022)

This work delineates a previously unrecognized role for NK cells in the antitumor immune response to radiotherapy that can be augmented by small-molecule DNA damage-response inhibitors and immune checkpoint blockade.

Keyphrases

dna damage response
nk cells
small molecule
early stage
dna repair
locally advanced
radiation induced
radiation therapy
high glucose
diabetic rats
protein protein
big data
squamous cell carcinoma
drug induced
dna damage
oxidative stress
machine learning
artificial intelligence