Impact of Integrase Strand Transfer Inhibitors on Cognition in the HAILO Cohort.

Jane A O'HalloranLuis Parra-RodriguezCharles W GossMansi AgarwalSarah CooleyKunling WuElizabeth WesterhausRachel PrestiBeau M AncesKatherine TassiopoulosKristine M Erlandsonnull null

Published in: Journal of acquired immune deficiency syndromes (1999) (2023)

NP performance improved regardless of INSTI use. There was an attenuation of improvement in verbal memory in the postswitch vs preswitch period. The clinical significance of these changes is unclear but, overall, INSTIs did not have a consistent detrimental effect on NP outcomes.

Keyphrases

working memory
mild cognitive impairment
white matter
multiple sclerosis
skeletal muscle