The Role of Bcl-2 and Beclin-1 Complex in "Switching" between Apoptosis and Autophagy in Human Glioma Cells upon LY294002 and Sorafenib Treatment.

Adrian ZającAleksandra MaciejczykJoanna Sumorek-WiadroKamil FilipekKamil DeryłoEwa LangnerJarosław PawelecMagdalena Wasiak Mateusz Ścibiorski Wojciech RzeskiMarek TchórzewskiMichał ReichertJoanna Jakubowicz-Gil

Published in: Cells (2023)

"Switching" between apoptosis and autophagy using PI3K and Raf inhibitors with Bcl-2:beclin-1 complex formation opens new therapeutic perspectives against gliomas.

Keyphrases

endoplasmic reticulum stress
cell death
oxidative stress
cell cycle arrest
endothelial cells
signaling pathway
high grade
pi k akt
smoking cessation