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COVID-19 infection during blinatumomab therapy: Is safety a dilemma?

Julián Esteban Barahona-CorreaCamilo Rueda-OrtizMaría-José LópezSandra GualteroMónica Arevalo-Zambrano
Published in: SAGE open medical case reports (2023)
Patients with acute lymphoblastic leukemia may be particularly vulnerable to SARS-CoV-2 infection and severe illness. The mainstay of current treatment is the use of blinatumomab in patients with refractory or relapsed B-cell precursor acute lymphoblastic leukemia. We discuss the case of a patient with relapsed acute lymphoblastic leukemia who became positive for SARS-CoV-2 during blinatumomab therapy. There are no formal recommendations on the decision to continue, withhold, or delay blinatumomab treatment in these patients. More studies exploring this issue are warranted, as SARS-CoV-2 is expected to be here to stay.
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