Advances in human stem cell technologies enable induced pluripotent stem cells (iPSCs) to be explored as potent candidates for treating various diseases, such as malignancies, autoimmunity, immunodeficiencies, and allergic reactions. iPSCs with infinite self-renewal ability can be derived from different types of somatic cells without the ethical issues associated with embryonic stem cells. To date, numerous cell types, including various immune cell subsets [CD4 + and CD8 + T cells, gamma delta T (γδ T) cells, regulatory T cells, dendritic cells, natural killer cells, macrophages, and neutrophils] have successfully been generated from iPSCs paving the way for effective adoptive cell transfer therapy, drug development, and disease modeling. Herein, we review various iPSC-derived immune cells and their possible application in immunotherapy.
Keyphrases
- induced pluripotent stem cells
- cell therapy
- stem cells
- regulatory t cells
- dendritic cells
- mesenchymal stem cells
- embryonic stem cells
- natural killer cells
- induced apoptosis
- immune response
- gene expression
- peripheral blood
- climate change
- dna methylation
- risk assessment
- bone marrow
- cell proliferation
- endoplasmic reticulum stress
- genome wide
- nk cells