Pirfenidone alleviates fibrosis by acting on tumour-stroma interplay in pancreatic cancer.

Yalan LeiJin XuMingming XiaoDi WuHe XuJing YangXiaoqi MaoHaoqi PanXian-Jun Yu Xianjun Yu

Published in: British journal of cancer (2024)

Pirfenidone may alter the pancreatic milieu and alleviate fibrosis through the regulation of tumour-stroma interactions via the TGM2/NF-kB/PDGFB signalling pathway, suggesting potential therapeutic benefits in PDAC management.

Keyphrases

idiopathic pulmonary fibrosis
pulmonary fibrosis
signaling pathway
lps induced
oxidative stress
liver fibrosis
pi k akt
nuclear factor
immune response
inflammatory response