Astragaloside IV combined with ligustrazine ameliorates abnormal mitochondrial dynamics via Drp1 SUMO/deSUMOylation in cerebral ischemia-reperfusion injury.

Xiangyu ChenTong YangYue ZhouZhi-Gang Mei Wenli Zhang

Published in: CNS neuroscience & therapeutics (2024)

This study posits that the combination of AST IV and Lig has the potential to reduce the SUMO-1ylation of Drp1, augment the SUMO-2/3ylation of Drp1, and thereby exert a protective effect against CIRI.

Keyphrases

ischemia reperfusion injury
oxidative stress
mouse model
risk assessment
climate change
cerebral blood flow