Bmi-1 regulates stem cell-like properties of gastric cancer cells via modulating miRNAs.

Xiaofeng WangChang WangXiaowei ZhangRuixi HuaLu GanMingzhu HuangLiqin ZhaoSujie NiWei-Jian Guo

Published in: Journal of hematology & oncology (2016)

Bmi-1 positively regulates stem cell-like properties via upregulating miR-21, and miR-34a negatively regulates stem cell-like characteristics by negative feedback regulation of Bmi-1 in gastric cancer. Bmi-1 upregulates miR-21 and miR-34a by activating AKT-NF-kB pathway.

Keyphrases

stem cells
cell proliferation
long non coding rna
signaling pathway
body mass index
long noncoding rna
weight gain
pi k akt
oxidative stress
immune response
weight loss