Aurora B kinase as a therapeutic target in acute lymphoblastic leukemia.

Hiroaki GotoYuki YoshinoMieko ItoJunichi NagaiTadashi KumamotoTakesi InukaiYukari SakuraiNaoyuki MiyagawaDai KeinoTomoko YokosukaFuminori IwasakiSatoshi HamanoueMasae ShiomiShoko Goto

Published in: Cancer chemotherapy and pharmacology (2020)

Aurora B kinase was identified to be an active therapeutic target in a broad range of ALL cells. Combination therapy of barasertib and a microtubule-targeting drug is of clinical interest.

Keyphrases

combination therapy
acute lymphoblastic leukemia
induced apoptosis
protein kinase
cell cycle arrest
tyrosine kinase
allogeneic hematopoietic stem cell transplantation
cancer therapy
endoplasmic reticulum stress
signaling pathway
oxidative stress
cell proliferation
acute myeloid leukemia