Development of a Physiologically-Based Pharmacokinetic Model of Δ9-Tetrahydrocannabinol in Mice, Rats, and Pigs.
Janthima MethaneethornKanyamas NaosangParichart KaewworasutChomkanang PoomsaidornManupat LohitnavyPublished in: European journal of drug metabolism and pharmacokinetics (2021)
A PBPK model of THC in mice, rats, and pigs was successfully developed and validated. This model can be further applied for inter-species extrapolation to humans.