Molecular Profiling of Hepatocellular Carcinoma Using Circulating Cell-Free DNA.

Ahmed O KasebNora S SánchezShiraj SenRobin K KelleyBenjamin TanAndrea G BocoboKian H LimReham Abdel-WahabMarc UemuraRoberto Carmagnani PestanaWei QiaoLianchun XiaoJeffrey MorrisHesham M AminManal M HassanAsif RashidKimberly C Banks Richard B LanmanAmirAli TalasazKenna R Mills-ShawBhawana GeorgeAbedul HaqueKanwal P S RaghavRobert A WolffJames C YaoFunda Meric-BernstamSadakatsu IkedaRazelle Kurzrock

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2019)

This study represents the first large-scale analysis of blood-derived ctDNA in HCC in United States. The genomic distinction based on HCC risk factors and the high percentage of potentially actionable genomic alterations suggests potential clinical utility for this technology.

Keyphrases

risk factors
copy number
single cell
risk assessment
single molecule
human health