KIF2A decreases IL-33 production and attenuates allergic asthmatic inflammation.

Zhengxia WangJingjing WuJingxian JiangQiyun MaMeijuan SongTingting XuYanan LiuZhongqi ChenYanmin BaoMao HuangMingshun ZhangNingfei Ji

Published in: Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology (2022)

KIF2A suppressed mTORC1-mediated autophagy and decreased the production of epithelial-derived cytokine IL-33 in allergic airway inflammation. These data indicate that KIF2A may be a novel target in allergic asthma.

Keyphrases

allergic rhinitis
oxidative stress
lung function
cell death
electronic health record
signaling pathway
big data
deep learning