INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression.
Tsima Abou KorsLinda HofmannAnnika C BetzlerKathrina PayerMartin BensJens TruongAdrian von WitzlebenJaya ThomasJohann M KrausRanda KalaajiehDiana HuberJasmin EzićJulian BenckendorffJens GrevePatrick J SchulerChristian Hermann OttensmeierHans Armin KestlerThomas K HoffmannMarie-Nicole TheodorakiCornelia BrunnerSimon LabanPublished in: Cancer research communications (2024)
Patients with HPV-negative OPSCC have a poorer prognosis due to distinct molecular pathways. This study reveals significant transcriptomic differences between HPV-negative and HPV-positive OPSCC, identifying INHBA as a key upregulated gene in HPV-negative OPSCC's oncogenic pathways. INHBA is crucial in promoting EMT, cell proliferation, and an immunosuppressive tumor environment, suggesting its potential as a therapeutic target for HPV-negative OPSCC.