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INHBA is Enriched in HPV-negative Oropharyngeal Squamous Cell Carcinoma and Promotes Cancer Progression.

Tsima Abou KorsLinda HofmannAnnika C BetzlerKathrina PayerMartin BensJens TruongAdrian von WitzlebenJaya ThomasJohann M KrausRanda KalaajiehDiana HuberJasmin EzićJulian BenckendorffJens GrevePatrick J SchulerChristian Hermann OttensmeierHans Armin KestlerThomas K HoffmannMarie-Nicole TheodorakiCornelia BrunnerSimon Laban
Published in: Cancer research communications (2024)
Patients with HPV-negative OPSCC have a poorer prognosis due to distinct molecular pathways. This study reveals significant transcriptomic differences between HPV-negative and HPV-positive OPSCC, identifying INHBA as a key upregulated gene in HPV-negative OPSCC's oncogenic pathways. INHBA is crucial in promoting EMT, cell proliferation, and an immunosuppressive tumor environment, suggesting its potential as a therapeutic target for HPV-negative OPSCC.
Keyphrases
  • high grade
  • squamous cell carcinoma
  • cell proliferation
  • cervical cancer screening
  • epithelial mesenchymal transition
  • papillary thyroid
  • copy number
  • cell cycle
  • lymph node metastasis