Login / Signup

Comprehensive analysis of damage evolution in human annulus fibrosus: Numerical exploration of mechanical sensitivity to biological age-dependent alteration.

Karim KandilFahmi ZaïriFahed Zaïri
Published in: Computers in biology and medicine (2024)
The findings challenge previous assumptions, showing that age-dependent microstructural changes have a notable effect on the annulus mechanical properties. The computational model closely aligns with experimental observations, underscoring the determinant role of oriented collagen fibers in radial failure. This study enhances the understanding of annulus failure and provides a foundation for further research on the impact of aging on disc mechanical integrity and failure.
Keyphrases
  • aortic valve
  • endothelial cells
  • oxidative stress
  • induced pluripotent stem cells
  • ultrasound guided