Uremic Toxic Blood-Brain Barrier Disruption Mediated by AhR Activation Leads to Cognitive Impairment during Experimental Renal Dysfunction.

Mickaël BobotLaurent ThomasAnaïs MoyonSamantha FernandezNathalie McKayLaure BalassePhilippe GarriguePauline BrigeSophie ChopinetStéphane PoitevinClaire CériniPhilippe BrunetFrançoise Dignat-GeorgeStéphane BurteyBenjamin GuilletGuillaume Hache

Published in: Journal of the American Society of Nephrology : JASN (2020)

AhR activation by indoxyl sulfate, a uremic toxin, leads to blood-brain barrier disruption associated with cognitive impairment in animal models of CKD.

Keyphrases

blood brain barrier
cognitive impairment
cerebral ischemia
escherichia coli
oxidative stress
subarachnoid hemorrhage