Cytotoxicity and exhaustion markers of chimeric antigen receptor T cells targeting BCMA in multiple myeloma cell lines between patients and healthy donors.

Somsak Prasongtanakij Sarinthip Preedagasamzin Bunyada Jittorntrum Usanarat Anurathapan Teeraya Puavilai Pimjai Niparuck Pichika Chantrathammachart Thanakrit Piyajaroenkij Kitipong Uaesoontrachoon Ryosuke Uchibori Keiya Ozawa Ken Ohmine Suradej Hongeng

Published in: European journal of haematology (2023)

Our BCMA CAR T cells, mainly effector/effector memory, could eliminate BCMA-expressing cells in vitro and had similar levels of exhaustion markers among different populations.

Keyphrases

end stage renal disease
multiple myeloma
induced apoptosis
ejection fraction
chronic kidney disease
dendritic cells
newly diagnosed
regulatory t cells
prognostic factors
drug delivery
type iii
patient reported outcomes
endoplasmic reticulum stress