Overcoming resistance in small-cell lung cancer.
Gerhard HamiltonMaximilian Johannes HochmairSandra SticklerPublished in: Expert review of respiratory medicine (2024)
The scarcity of viable tumor specimen from relapsed SCLC patients has hampered the investigations of acquired chemoresistance but a panel of nine SCLC circulating tumor cell (CTC) cell lines have revealed characteristics of SCLC in the advanced refractory states. The chemoresistance of relapsed SCLC seems to be linked to the spontaneous formation of large spheroids, termed tumorospheres, which contain resistant quiescent and hypoxic cells shielded by a physical barrier. So far, drugs to tackle large tumor spheroids are in preclinical and early clinical development.
Keyphrases
- circulating tumor
- small cell lung cancer
- acute lymphoblastic leukemia
- acute myeloid leukemia
- end stage renal disease
- single cell
- multiple myeloma
- circulating tumor cells
- diffuse large b cell lymphoma
- ejection fraction
- hodgkin lymphoma
- cell therapy
- newly diagnosed
- induced apoptosis
- chronic kidney disease
- physical activity
- prognostic factors
- cell cycle arrest
- oxidative stress
- patient reported outcomes
- cell death
- signaling pathway