Periodontitis-compromised dental pulp stem cells secrete extracellular vesicles carrying miRNA-378a promote local angiogenesis by targeting Sufu to activate the Hedgehog/Gli1 signalling.

Huan ZhouXuan LiRui-Xin WuXiao-Tao HeYing AnXin-Yue XuHai-Hua SunLi-An WuFa-Ming Chen

Published in: Cell proliferation (2021)

These data suggest that P-EVs carrying miR-378a promote EC angiogenesis by downregulating Sufu to activate the Hedgehog/Gli1 signalling pathway. Our findings reveal a crucial role for EV-derived miR-378a in cell angiogenesis and hence offer a new target for modifying stem cells and their secreted EVs to enhance vessel regenerative potential.

Keyphrases

stem cells
endothelial cells
cell therapy
cell proliferation
vascular endothelial growth factor
long non coding rna
long noncoding rna
single cell
wound healing
genome wide
big data
bone marrow
dna methylation
data analysis