Dual activation of Toll-like receptors 7 and 9 impairs the efficacy of antitumor vaccines in murine models of metastatic breast cancer.

Mariela A Moreno AyalaMaría Florencia GottardoMaría Soledad GoriAlejandro Javier Nicola CandiaCarla CarusoAndrea De LaurentiisMercedes ImsenSlobodanka KleinElisa Bal de Kier JofféGabriela SalamoneMaria G CastroAdriana SeilicovichMarianela Candolfi

Published in: Journal of cancer research and clinical oncology (2017)

These observations provide insight in the biology of TLR9 and TLR7 crosstalk and suggest caution in the selection of agonists for multiple TLR stimulation. Blockade of NOS and IDO could improve the maturation of antitumor DC vaccines. R848 could prove a useful adjuvant for DC vaccines in human patients.

Keyphrases

toll like receptor
inflammatory response
metastatic breast cancer
immune response
end stage renal disease
ejection fraction
endothelial cells
dendritic cells
chronic kidney disease
early stage
nuclear factor
peritoneal dialysis
patient reported outcomes
induced pluripotent stem cells
patient reported