The time-dependent impact of type 2 diabetes mellitus on incident prodromal Alzheimer's disease: a longitudinal study in 1395 participants.

Tong LuoYun-Feng TuShan HuangYuan-Yuan MaQing-Hua WangYan-Jiang WangJun Wangnull null

Published in: European journal of neurology (2023)

T2DM, which is characterized by a longer duration, increases the incidence risk of prodromal AD but not AD dementia. APOE ε4 allele and comorbid CAD strengthen the relationship between T2DM and prodromal AD. These findings highlight T2DM characteristics and its comorbidities as predictors for accurate prediction of AD and screening of at-risk populations.

Keyphrases

parkinson disease
glycemic control
cognitive decline
mild cognitive impairment
coronary artery disease
cardiovascular disease
risk factors
high fat diet
adipose tissue
metabolic syndrome
high resolution
mass spectrometry
cardiovascular risk factors