Zn(ii)-Coordination-driven self-assembled nanoagents for multimodal imaging-guided photothermal/gene synergistic therapy.
Hui HuNan YangJiahui SunFu ZhouRui GuYuan LiuLi WangXuejiao SongRuirui YunXiaochen DongGuangfeng WangPublished in: Chemical science (2022)
Synergistic photothermal therapy (PTT) with gene therapy (GT) has drawn emerging interest in the improvement of cancer therapeutic efficiency, while the co-delivery of photothermal agents (PTAs) and therapeutic genes by an integrated nanoplatform, with controllability and biodegradability, is still challenging and urgently desired. Herein, a multi-functional metal-organic framework (MOF) based PTT-GT platform (siRNA@PT-ZIF-8) was developed, which was constructed with siRNA, a near-infrared (NIR) responsive organic dye IR780 derivative (IR780-1), and 2-methylimidazole (2-MIM) by a facile one-pot self-assembly method. This "all-in-one" system of siRNA@PT-ZIF-8 enabled not only photothermal/photoacoustic/fluorescence multimodal imaging but also tumor microenvironment responsiveness for specific and on-demand release of therapeutic cargos, overcoming the inherent limitations of free gene or organic PTA molecules ( e.g. , short blood circulation half-life and weak stability) in conventional PTT and GT. This nanoplatform provides an efficient and safe strategy for cancer theranostics, and the one-step assembly strategy favors personalized formulation design for diverse demands in cancer management.
Keyphrases
- cancer therapy
- drug delivery
- photodynamic therapy
- metal organic framework
- papillary thyroid
- drug release
- gene therapy
- genome wide
- squamous cell
- high resolution
- fluorescence imaging
- pain management
- copy number
- genome wide identification
- childhood cancer
- high throughput
- mesenchymal stem cells
- mass spectrometry
- lymph node metastasis
- stem cells
- quantum dots
- heavy metals
- gene expression
- highly efficient
- reduced graphene oxide
- gold nanoparticles
- genome wide analysis
- smoking cessation