Circulating CXCR5-PD-1hi peripheral T helper cells are associated with progression to type 1 diabetes.

Ilse EkmanEmmi-Leena IhantolaTyyne ViisanenDeepak A RaoKirsti Näntö-SalonenMikael KnipRiitta VeijolaJorma ToppariJorma IlonenTuure Kinnunen

Published in: Diabetologia (2019)

Our results demonstrate that circulating CXCR5-PD-1hi Tph cells are associated with progression to clinical type 1 diabetes. Consequently, Tph cells could have potential both as a biomarker of disease progression and as a target for immunotherapy in type 1 diabetes.

Keyphrases

type diabetes
induced apoptosis
cell cycle arrest
cardiovascular disease
glycemic control
signaling pathway
cell death
immune response
metabolic syndrome
dendritic cells
cell proliferation
risk assessment
regulatory t cells
weight loss
pi k akt