Chitinase 3 like 1 suppresses the stability and activity of p53 to promote lung tumorigenesis.

Kyung-Ran ParkHyung-Mun YunKyeongwon YooYoung Wan HamSang Bae HanJin Tae Hong

Published in: Cell communication and signaling : CCS (2020)

Our studies suggest that intracellular Chi3L1 plays a critical role in the lung tumorigenesis by regulating its novel target protein, p53 in both an in vitro and in vivo system.

Keyphrases

signaling pathway
protein protein
small molecule