Long-Term Intake of Proton-Pump Inhibitors Could Be Associated with an Increased Incidence of Liver Cancer in Women.
Sven Heiko LoosenMarkus Sebastian JördensCatherine LeyhTom LueddeChristoph RoderburgKarel KostevPublished in: Cancers (2024)
Our data suggest that long-term PPI intake in women as well as in patients < 60 years might be associated with an increased risk of liver cancer. These findings support current efforts to reduce the inappropriate use of PPIs in routine clinical practice and to link PPI prescribing to a clear medical indication.
Keyphrases
- clinical practice
- polycystic ovary syndrome
- end stage renal disease
- ejection fraction
- primary care
- newly diagnosed
- healthcare
- chronic kidney disease
- prognostic factors
- weight gain
- protein protein
- risk factors
- emergency department
- cervical cancer screening
- adipose tissue
- type diabetes
- big data
- body mass index
- insulin resistance
- machine learning
- breast cancer risk
- skeletal muscle
- patient reported outcomes
- physical activity
- data analysis
- patient reported
- adverse drug