Methadone dosing strategies in preterm neonates can be simplified.

Tamara van DongeSamira Samiee-ZafarghandyMarc PfisterGilbert KochMajid KalaniArash BordbarJohn van den Anker

Published in: British journal of clinical pharmacology (2019)

Methadone clearance in preterm neonates increases with advancing gestational age and its disposition is influenced by its chirality. Simulations that account for developmental PK changes indicate a shorter methadone dosing strategy can maintain target exposure to control withdrawal symptoms.

Keyphrases

gestational age
low birth weight
preterm birth
birth weight
preterm infants
molecular dynamics
sleep quality