Incidence and risk factors of anti-tuberculosis drug induced liver injury (DILI): Large cohort study involving 4652 Chinese adult tuberculosis patients.

Fanrong JiangHuadong YanLili LiangJingyuan DuSusu JinShiqing YangHongxia WangTing HuYuying ZhuGuangming WangYaoren HuTing CaiGuruprasad Padur Aithal

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

Elevation of ALT of ≥3 × ULN during anti-TB treatment resolves in the vast majority without developing serious consequences. In two cohorts involving 4652 patients, incidence of ALF and death because of ATDILI are low. Age, baseline ALT, haemoglobin and HBsAg positivity are risk factors for the development of DILI and these inform monitoring and management of these patients.

Keyphrases

end stage renal disease
newly diagnosed
ejection fraction
chronic kidney disease
peritoneal dialysis
mycobacterium tuberculosis
prognostic factors
emergency department
risk factors
hepatitis b virus
drug induced
human immunodeficiency virus
patient reported outcomes
adverse drug