Xenogeneic Neu5Gc and self-glycan Neu5Ac epitopes are potential immune targets in MS.
Kayluz F BoliganJohanna OechteringChristian W KellerBenjamin PeschkeRobert RiebenNicolai BovinLudwig KapposRichard D CummingsJens KuhleStephan von GuntenJan D LünemannPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
Patients with MS show increased IgG reactivities to structurally related xenogeneic and human neuraminic acids. The discovery of these glycan-specific epitopes as immune targets and potential biomarkers in MS merits further investigation.