PNOC015: Repeated convection enhanced delivery (CED) of MTX110 (aqueous panobinostat) in children with newly diagnosed diffuse intrinsic pontine glioma (DIPG).

Romain Mueller Cassie N Kline Schuyler Stoller Shannon LundyLauren ChristopherAlyssa T Reddy Anu BanerjeeTabitha M CooneyShannon RaberCarly HoffmanTracy LuksEva Wembacher-SchroederNina LummelYalan ZhangErin R BonnerJavad Nazarian Annette M Molinaro Michael D Prados Javier E Villanueva-Meyer Nalin Gupta

Published in: Neuro-oncology (2023)

Repeat CED of MTX110 with real time imaging with gadoteridol is tolerable for patients with DIPG. Median OS of 26.1 months compares favorably with historical data for children with DIPG. The results support further investigation of this strategy in a larger cohort.

Keyphrases

newly diagnosed
young adults
high resolution
electronic health record
low grade
big data
machine learning
data analysis