Widespread loss of the silencing epigenetic mark H3K9me3 in astrocytes and neurons along with hippocampal-dependent cognitive impairment in C9orf72 BAC transgenic mice.
Nur JurySebastian AbarzuaIvan DiazMiguel V GuerraEstibaliz AmpueroPaula CubillosPablo MartinezAndrea Herrera-SotoCristian ArredondoFabiola RojasMarcia ManterolaAdriana RojasMartín MontecinoLorena Varela-NallarBrigitte van ZundertPublished in: Clinical epigenetics (2020)
Our data indicate that a loss of the repressive mark H3K9me3 in astrocytes and neurons in the central nervous system of C9BAC mice represents a signature during neurodegeneration and memory deficit of C9ALS/FTD.