Specific profile of ultrasonic communication in a mouse model of neurodevelopmental disorders.
Marika PremoliSara Anna BoniniAndrea MastinuGiuseppina MaccarinelliFrancesca AriaGiulia PaiardiMaurizio MemoPublished in: Scientific reports (2019)
Mice emit ultrasonic vocalizations (USVs) in different social conditions: pups maternal separation, juveniles play, adults mating and social investigation. The USVs measurement has become an important instrument for behavioural phenotyping in neurodevelopmental disorders (NDDs). Recently, we have demonstrated that the deletion of the NFκB1 gene, which encodes the p50 NF-κB subunit, causes NDDs phenotype in mice. In this study, we investigated the ultrasonic communication and the effects of an early social enrichment in mice lacking the NF-κB p50 subunit (p50 KO). In particular, USVs of wild-type (WT), p50 KO and KO exposed to early social enrichment (KO enriched) were recorded using an ultrasound sensitive microphone and analysed by Avisoft software. USVs analysis showed that p50 KO pups emit more and longer vocalizations compared to WT pups. On the contrary, in adulthood, p50 KO mice emit less USVs than WT mice. We also found significant qualitative differences in p50 KO mice USVs compared to WT mice; the changes specifically involved two USVs categories. Early social enrichment had no effect on USVs number, duration and type in p50 KO mice. Together, these data revealed social communication alterations in a mouse model of NDDs; these deficits were not recovered by early social enrichment, strengthening the fact that genetic background prevails on environmental enrichment.
Keyphrases
- wild type
- high fat diet induced
- healthcare
- mouse model
- mental health
- signaling pathway
- insulin resistance
- type diabetes
- oxidative stress
- magnetic resonance imaging
- machine learning
- metabolic syndrome
- physical activity
- computed tomography
- pregnant women
- traumatic brain injury
- lps induced
- gene expression
- pi k akt
- weight loss
- adipose tissue
- genome wide
- skeletal muscle
- climate change
- cell proliferation
- high throughput
- copy number
- big data
- genome wide identification