Multicellular "hotspots" harbor high-grade potential in lower-grade gliomas.

Alastair J KirbyJosé P LavradorIstvan BodiFrancesco VerganiRanjeev BhangooKeyoumars AshkanGerald T Finnerty

Published in: Neuro-oncology advances (2021)

Our data show that PpIX hotspots represent microdomains of cells with high-grade potential within lower-grade gliomas and identify locations where malignant progression could start.

Keyphrases

high grade
low grade
induced apoptosis
cell cycle arrest
human health
electronic health record
oxidative stress
big data
cell proliferation
machine learning
signaling pathway
cell death
deep learning
climate change