Acute Graft-Versus-Host Disease: A Brief Review
Elifcan AladagEngin KelkitliHakan GokerPublished in: Turkish journal of haematology : official journal of Turkish Society of Haematology (2019)
Graft‐versus‐host disease (GvHD) is an important complication that can be observed after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Acute GvHD (aGvHD) is seen after allo-HSCT and the incidence of aGvHD is around 30%-50%. aGvHD prophylaxis is essential in patients undergoing allo-HSCT. Initial therapy for aGvHD is steroids. Prognosis is poor in aGvHD patients not responding to steroids. In this article, the pathobiology, clinical findings, prophylaxis, and treatment of aGvHD will be summarized.
Keyphrases
- allogeneic hematopoietic stem cell transplantation
- liver failure
- acute myeloid leukemia
- acute lymphoblastic leukemia
- patients undergoing
- end stage renal disease
- hematopoietic stem cell
- respiratory failure
- ejection fraction
- drug induced
- risk factors
- prognostic factors
- peritoneal dialysis
- intensive care unit
- extracorporeal membrane oxygenation
- mechanical ventilation