Beneficial effects of a new neuroprotective compound in neuronal cells and MPTP-administered mouse model of Parkinson's disease.

Izumi KatoYudai OgawaFumika YakushijiJiro OguraMasaki KobayashiNaoya Shindo Satoshi Ichikawa Katsumi MaenakaMasahiro Sakaitani

Published in: Chemical communications (Cambridge, England) (2023)

A new compound, a derivative of 3,4,5-trimethoxy- N -phenyl benzamide bearing an 8''-methylimidazopyridine moiety, is found to demonstrate neuroprotective effects by preventing cell death caused by oxidative stress. The compound possesses high solubility and metabolic stability, and inhibits MPTP-induced effects in vivo , indicating high potential as a therapeutic drug for Parkinson's disease.

Keyphrases

cell death
oxidative stress
induced apoptosis
mouse model
cell cycle arrest
diabetic rats
cerebral ischemia
endoplasmic reticulum stress
ischemia reperfusion injury
risk assessment
cell proliferation
human health
brain injury
endothelial cells
adverse drug
climate change
water soluble
heat shock protein