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First familial cases of P102L Gerstmann-Sträussler-Scheinker syndrome in South Korea: diffusion-weighted imaging might reflect intrafamilial phenotypic variability.

Seon-Jae AhnHan Sang LeeJangsup MoonKon Chu
Published in: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology (2022)
We genetically confirmed familial cases of GSS in South Korea. Although the disease is extremely rare, the PRNP gene test should be considered in undiagnosed autosomal dominant hereditary cerebellar ataxia. Phenotypical variability of GSS may be reflected in DWI of the early phase of the disease.
Keyphrases
  • diffusion weighted imaging
  • early onset
  • magnetic resonance imaging
  • contrast enhanced
  • copy number
  • magnetic resonance
  • gene expression
  • case report
  • computed tomography
  • dna methylation
  • genome wide identification