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Survivin Dendritic Cell Vaccine Safely Induces Immune Responses and Is Associated with Durable Disease Control after Autologous Transplant in Patients with Myeloma.

Ciara Louise FreemanReginald AtkinsIndumathy VaradarajanMeghan MengesJeffrey EdelmanRachid C BazJason BrayerOmar Castaneda PuglianiniJose Leonel Ochoa-BayonaTaiga NishihoriKenneth H ShainBijal D ShahDung Tsa ChenLinda KelleyDomenico CoppolaMelissa AlsinaScott J AntoniaClaudio AnasettiFrederick L Locke
Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Two doses of DC:Ad-S, one given immediately before and another after ASCT, were feasible and safe. A high frequency of vaccine-specific immune responses was seen in combination with durable clinical outcomes, supporting ongoing investigation into the potential of this approach.
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