PM2.5 exposure induces systemic inflammation and oxidative stress in an intracranial atherosclerosis rat model.

Longfei GuanXiaokun GengChristopher StoneEric E P CoskyYu JiHuishan DuKezhong ZhangQinghua SunYuchuan Ding

Published in: Environmental toxicology (2019)

PM2.5 exposure induced systemic inflammation, cerebrovascular oxidative injury, and ICA in rats with HCD. O3FA prevented ICA development, and may therefore exert a protective effect against the atherogenic potential of PM2.5 .

Keyphrases

particulate matter
air pollution
polycyclic aromatic hydrocarbons
oxidative stress
diabetic rats
heavy metals
water soluble
cardiovascular disease
high glucose
dna damage
ischemia reperfusion injury
type diabetes