Diastereoselective additions of H-phosphinates to alkenyl ketones under phase-transfer conditions.
Krishna P YadavalliJohannah E CumminesChace J CarlisleSalvatore D LeporePublished in: Chemical communications (Cambridge, England) (2022)
Additions of bulky H-phosphinates to β,β-disubstituted alkenyl ketones under the action of a phase transfer-catalyst led to a new class of carbon quaternary center-containing phosphinates with unprecedented control of the relative configuration of the adjacent carbon and phosphorous chiral centers with high diastereoselectivity in most cases.